威尼斯游戏大厅

牛雪梅
研究员/ xmniu@ynu.edu.cn/微生物学

个人简历

2007.11-至今      云南大学                   研究员、博导

2013.7-2014.7     美国休斯顿健康医疗中心     访问学者

2006.04-2007.07   德国马普化学生态研究所     博士后

2004.10-2006.03   德国莱布尼兹天然产物及感染生物学研究所  博士后

2004.03-2004.09   香港中文大学               博士后

1999.03-2004.02   中国科学院昆明植物研究所  博士、助理/副研究员

1989.09-1999.02   广西师范大学               学士、硕士、讲师


主要研究方向

主要从事抗线虫真菌天然产物及线虫病原真菌的化学、功能及生物合成研究,重点开展以下两个方面的研究:

1. 从真菌中新型抗线虫先导化合物发现与挖掘,及重要活性分子的生物合成。

2. 从重要线虫生防真菌中解析杀死和调控寄主的,以及调控捕食线虫真菌形态,参与繁殖和捕食等生物过程的活性小分子化合物的结构及相关生物合成基因


主要论文

  1. Zi-Fei Xu, Yong-Hong Chen, Tian-Yang Song, Zhi-Jun Zeng, Ni Yan, Ke-Qin Zhang, and Xue-Mei Niu*.Nematicidal Key Precursors for the Biosynthesis of Morphological Regulatory Arthrosporols in the Nematode-Trapping Fungus Arthrobotrys oligospora. Journal of Agricultural and Food Chemistry, 2016, 64, 7949−7956, DOI:10.1021/acs.jafc6b03241.  (*corresponding author)

  2. Zi-Fei Xu, Bai-Le Wang, Hong-Kai Sun, Ni Yan, Zhi-Jun Zeng, Ke-Qin Zhang, and Xue-Mei Niu*. High Trap Formation and Low Metabolite Production by Disruption of the Polyketide Synthase Gene Involved in the Biosynthesis of Arthrosporols from Nematode-Trapping Fungus Arthrobotrys oligospora. Journal of Agricultural and Food Chemistry, 2015, 63, 9076-9082.  (*corresponding author)

  3. Yan-li Wang, Lin-fang Li, Dong-xian Li, Baile Wang, Keqin Zhang,* and Xuemei Niu*. Yellow Pigment Aurovertins Mediate Interactions between the Pathogenic Fungus Pochonia chlamydosporia and Its Nematode Host. Journal of Agricultural and Food Chemistry, 2015, 63, 6577-87.  (*corresponding author)

  4. Li Chen, Qun Yue, Yan Li, Xue-Mei Niu, Meichun Xiang, Wenzhao Wang, Gerald Bills, Xingzhong Liu, and Zhiqiang An "Engineering of Glarea lozoyensis for the exclusive production of the pneumocandin B0 precursor of the antifungal drug caspofungin acetate. Applied and Environmental Microbiology, 2015, 81(5):1550-8. doi: 10.1128/AEM.03256-14

  5. Juan Li, Chenggang Zou, Jianping Xu, Xinglai Ji, Xuemei Niu, Jinkui Yang, XiaoweiHuang, and Ke-Qin Zhang. Molecular mechanisms of nematode-nematophagous microbe interactions: basis for biological control of plant-parasitic nematodes. Annual Review of Phytopathology, 2015, 53:67–95.

  6. Qun Yue, Li Chen, Yan Li, Gerald F Bills, Xinyu Zhang, Meichun Xiang, Shaojie Li, Yongsheng Che, Chengshu Wang, Xuemei Niu, Zhiqiang An, and Xingzhong Liu. Functional operons in secondary metabolic gene clusters in Glarea lozoyensis (Fungi, Ascomycota, Leotiomycetes). mBio, 2015, 6(3): e00703-15.

  7. Xue-Mei Niu*, Li Chen, Qun Yue, Baile Wang, Junxian Zhang, Chunyan Zhu, Keqin Zhang, Gerald F. Bills, and Zhiqiang An. Characterization of Thermolide Biosynthetic Genes and a New Thermolide from Sister Thermophilic Fungi. Organic Letters, 2014, 16 (14): 3744-3747. (*corresponding author)

  8. Xin Wang, Guo-Hong Li, Cheng-Gang Zou, Xing-Lai Ji, Tong Liu, Pei-Ji Zhao, Lian-Ming Liang, Jian-Ping Xu, Zhi-Qiang An, Xi Zheng, Yue-Ke Qin, Meng-Qing Tian, You-Yao Xu,Yi-Cheng Ma, Ze-Fen Yu, Xiao-Wei Huang, Shu-Qun Liu, Xue-Mei Niu, Jin-Kui Yang, Ying Huang and Ke-Qin Zhang. Bacteria can mobilize nematode-trapping fungi to kill nematodes. Nature Communications, 2014, 5: 5776.

  9. Shu-Xi Jing, Shi-Hong Luo, Chun-Huan Li, Juan Hua, Yan-Li Wang, Xue-Mei Niu, Xiao-Nian Li, Yan Liu, Chun-Shuai Huang, Ying Wang, Sheng-Hong Li. Biologically Active Dichapetalins from Dichapetalum gelonioides. Journal of Natural Products, 2014, 77, 882-893.

  10. Gerald Bills, Yan Li, Li Chen, Qun Yue, Xue-Mei Niu and Zhiqiang An. New insights into the echinocandins and other fungal non-ribosomal peptides and peptaibiotics. Natural Product Reports, 2014, 31: 1348-1375.

  11. De-Kai Wu, Chuan-Ping Zhang, Chun-Yan Zhu, Yan-Li Wang, Li-Lei Guo, Ke-Qin Zhang, and Xue-Mei Niu*. Metabolites from Carnivorous Fungus Arthrobotrys entomopaga and Their Functional Roles in Fungal Predatory Ability, Journal of Agricultural and Food Chemistry, 2013, 61: 4108-4113.  (*corresponding author)

  12. ShiHong Luo, Juan Hua, Xue-Mei Niu, Yan Liu, ChunHuan Li, YanYing Zhou, ShuXi Jing, Xu Zhao, ShengHong Li, Defense sesterterpenoid lactones from Leucosceptrum canum, Phytochemistry, 2013, 86: 29 - 35.

  13. Jianlin Tan, Xue-Mei Niu, Guangyu Yang, Lang Wang, Yuanxing Duan, Yi Han, Keqin Zhang, Chengming Zhang. Quantitative Determination of Free Phytosterols in Tobacco Leaves by UPLC-MS/MS. Journal of Liquid Chromatography & Related Technologies. 2013, 36: 591-599.

  14. 李娟,彭德良,廖金铃,简恒,牛雪梅,刘杏忠,张克勤,农作物重要病原线虫生物防控的研究进展,生命科学, 01, pp 8-15, 2013

  15. Ji-Peng Guo, Chun-Yan Zhu, Chuan-Ping Zhang, Yan-Sheng Chu, Yan-Li Wang, Jun-Xian Zhang, De-Kai Wu, Ke-Qin Zhang, Xue-Mei Niu*. Thermolides, Potent Nematocidal PKS-NRPS Hybrid Metabolites from Thermophilic Fungus Talaromyces thermophilus, Journal of the American Chemical Society, 2012, 134(50): 20306-20309. (*corresponding author)

  16. Sheng-Hong Li, Nina Elisabeth Nagy, Almuth Hammerbacher, Paal Krokene, Xue-Mei Niu, Jonathan Gershenzon, Bernd Schneider. Localization of Phenolics in Phloem Parenchyma Cells of Norway Spruce (Picea abies), ChemBioChem, 2012, 13(18): 2707 - 2713.

  17. Hui-Xiang Zhang, Jian-Lin Tan, Lu-Xia Wei, Yan-Li Wang, Chuan-Ping Zhang, De-Kai Wu, Chun-Yan Zhu, Ying Zhang,  Ke-Qin Zhang, Xue-Mei Niu*. Morphology Regulatory Metabolites from Arthrobotrys oligospora. Journal of Natural Products, 2012, 75 (7): 1419-1423. (*corresponding author)

  18. Hong-Yang Wu, Yan-Li Wang, Jian-Lin Tan, Chun-Yan Zhu, Dong-Xian Li, Rong-Huang, Ke-Qin Zhang, Xue-Mei Niu*. Regulation of the Growth of Cotton Bollworms by Metabolites from an Entomopathogenic Fungus Paecilomyces cateniobliquus. Journal of Agricultural and Food Chemistry, 2012, 60(22): 5604-5608. (*corresponding author)

  19. Shi-Hong Luo, Yan Liu, Juan Hua, Xue-Mei Niu,  Shu-Xi Jing,  Xu Zhao, Bernd Schneider, Jonathan Gershenzon, Sheng-Hong Li, Unique Proline-Benzoquinone Pigment from the Colored Nectar of "Bird's Coca Cola Tree" Functions in Bird Attractions. Organic Letters, 2012, 14(16): 4146-4149.

  20. Lei Li, MingChuan Ma, Rong Huang, Qing Qu, GuoHong Li, JinWei Zhou, KeQin Zhang, KaiPing Lu, XueMei Niu, Jun Luo, Induction of Chlamydospore Formation in Fusarium by Cyclic Lipopeptide Antibiotics from Bacillus subtilis C2. Journal of Chemical Ecology, 2012, 38: 966-974.

  21. Ji-Peng Guo, Jian-Lin Tan, Yan-Li Wang, Hong-Yang Wu, Chuan-Ping Zhang, Xue-Mei Niu*, Wen-Zheng Pan, Xiao-Wei Huang, Ke-Qin Zhang. Isolation of Talathermophilins from a Thermophilic Fungus Talaromyces thermophilus YM3-4. Journal of Natural Products, 2011, 74(10), 2278-2281. (*corresponding author)

  22. Lu-Xia Wei, Hui-Xiang Zhang, Jian-Lin Tan, Yan-Sheng Chu, Nan Li, Hua-Xi Xue, Yan-Li Wang,  Xue-Mei Niu*,  Ying Zhang, Ke-Qin Zhang. Arthrobotrisins A-C, Oligosporons from the Nematode-Trapping Fungus Arthrobotrys oligospora. Journal of Natural Products, 2011, 74(6): 1526-1530. (*corresponding author)

  23. Xue-Mei Niu, Ke-Qin Zhang. Arthrobotrys oligospora: a Model Organism for Understanding the Interaction between Fungi and Nematodes. Mycology, 2011, 2(2): 59-78.

  24. Yan-Sheng Chu, Xue-Mei Niu*, Yan-Li Wang, Ji-Peng Guo, Wen-Zheng Pan, Xiao-Wei Huang, Ke-Qin Zhang. Isolation of Putative Biosynthetic Intermediates of Prenylated Indole Alkaloids from a Thermophilic Fungus Talaromyces thermophilus. Organic Letters, 2010, 12(19): 4356-4359. (*corresponding author)

  25. Xue-Mei Niu, Yan-li Wang, Yansheng Chu, Huaxi Xue, Nan Li, Luxia Wei, Minghe Mo, Keqin Zhang. Nematodetoxic Aurovertin-Type Metabolites from a Root-Knot Nematode Parasitic Fungus Pochonia chlamydosporia. Journal of Agricultural and Food Chemistry, 2010, 58(2): 828-834.

  26. Chun-Huan Li, Xue-Mei Niu, Qian Luo, Ming-Jin Xie, Shi-Hong Luo, Yan-Ying Zhou, Sheng-Hong Li. Novel Polyesterified 3,4-seco-Grayanane Diterpenoids as Antifeedants from Pieris formosa. Organic Letters, 2010, 12(10): 2426-2429.

  27. Shi-Hong Luo, Qian Luo, Xue-Mei Niu, Ming-Jin Xie, Xu Zhao, Bernd Schneider, Jonathan Gershenzon, Sheng-Hong Li. Glandular Trichomes of Leucosceptrum canum Harbor Defensive Sesterterpenoids. Angewandte Chemie International Edition, 2010, 49: 4471-4475.

  28. Qiuhong Niu, Xiaowei Huang, Lin Zhang, Jianping Xu, Dongmei Yang, Kangbi Wei, Xuemei Niu, Zhiqiang An, Joan Wennstrom Bennett, Chenggang Zou, Jinkui Yang, Ke-Qin Zhang. A Trojan Horse Mechanism of Bacterial Pathogenesis against Nematodes. Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (38): 16631-16636.