威尼斯游戏大厅

孙建伟
教授(招生专业方向:细胞生物学)/ jwsun@ynu.edu.cn /线粒体功能调控与肿瘤发生

  个人简介

   

 

云南大学生命科学中心 研究员,博士生导师

威尼斯游戏大厅 生化与细胞生物学

 

孙建伟博士2010年于中国科学院遗传与发育生育学研究所获博士学位。2011-2015年在美国佛罗里达MOFFITT癌症研究中心从事博士后研究。2015年进入华南农业大学工作。2018年调入云南大学生命科学中心研究员。以通讯/第一作者身份在Journal of Cell Biology、Oncogene、Journal of Biological Chemistry等国际一流学术期刊发表多篇研究论文。

 

实验室研究方向

1. 肿瘤的发生与肿瘤抗药性

2. 线粒体功能的调控

3. 抗肿瘤药物的筛选


招生硕士点专业方向:细胞生物学

 

代表性研究论文

1. Jian Wang, Junling Shen, Kaili Zhao, Jinmeng Hu, Jiuxing Dong and Jianwei Sun*. STIM1 overexpression in hypoxia microenvironment contributes to pancreatic carcinoma progression. Cancer Biology & Medicine. 2019 (In press)

 

2. Fujian Lu#, Jianwei Sun#, Jinghang Li, Yuanzhao Hu, Peng Yu, Huifang He, Yan Zhao, Xianhua Wang, Shengyu Yang* and Heping Cheng*. Imaging STIM1-Orai1 Ca2+ Sparks in Invading Cancer Cells with Targeted Sensors. Journal of Cell Sciences. 2019(In press) (#共同第一作者)

 

3. Jiaxin Kang, Jian Wang, Zhuang YaoYuanzhao Hu, Shijie MaQin FanYan Sun* and Jianwei Sun*. Fascin induce melanoma tumorgenesis and stemness through regulating TAZ stability. Cell Communication and signaling 2018 Jul 3:16(1):37. doi: 10.1186/s12964-018-0250-1.

 

4. Shengchen Lin, Shuang Lu, Mentor Mulaj, Bin Fang, Tyler Keeley, Lixin Wan, Jihui Hao, Martin Muschol, Jianwei Sun* and Shengyu Yang*. Monoubiquitination Inhibits the Actin Bundling Activity of Fascin . Journal of Biological Chemistry. 2016 Dec 30;291(53):27323-27333. (*共同通讯作者)

 

5. Jaw-Yuan Wang#, Jianwei Sun#, Ming-Yii Huang, Ming-Feng Hou, Yu-Shiuan Wang, Yan Sun, Yao-Ting Tsai, Huifang He, Shengchen Lin, Shengyu Yang, and Wei-Chiao Chang. STIM1 Overexpression promoted Colorectal Cancer Progression, Cell Motility and COX-2 Expression. Oncogene, 2015 Aug 13;34(33):4358-67. (#共同第一作者)

 

6. Jianwei Sun, Fujian Lu, Huifang He, Junling Shen, Jane Messina, Rahel Mathew, Dapeng Wang, Amod A. Sarnaik, Wei-Chiao Chang, Minjung Kim, Heping Cheng, and Shengyu Yang. STIM1- and Orai1-mediated Ca2+ oscillation orchestrates invadopodium formation and melanoma invasion. Journal of Cell Biology. 2014 Nov 24, 207(4): 535-548. (同期JCB研究焦点评述: Mitch Leslie. Melanoma cells travel on calcium cycles. http://jcb.rupress.org/content/early/2014/11/10/jcb.2074iti3)

7Jianwei Sun, Huifang He, Smitha Pillai, Yin Xiong, Sridevi Challa, Liyan Xu, Srikumar Chellappan and Shengyu Yang. GATA3 Transcription Factor Abrogates Smad4 Transcription Factor-mediated Fascin Overexpression, Invadopodium Formation, and Breast Cancer Cell Invasion. Journal of Biological Chemistry. 2013 Dec 27;288(52):36971-82.

 

8. Jianwei Sun, Huifang He, Yin Xiong, Shuang Lu, Junling Shen, Anna Cheng, Wei-Chiao Chang,Ming-Feng Hou, Johnathan M. Lancaster, Minjung Kim and Shengyu Yang. Fascin Protein Is Critical for Transforming Growth Factor Protein-induced Invasion and Filopodia Formation in Spindle-shaped Tumor Cells. Journal of Biological Chemistry 2011, 286(45): 38865–38875. 

 

 

实验室成员和在读研究生

硕士生:商荣磊,白韦钰,孙瑞